What is Serrapeptase? Benefits, Side Effects and FAQ

Updated on December 8, 2022
Lauren Long By Lauren Long
Lauren Long

Creative Writer, Lifestyle Blogger, and Skincare and Wellness Enthusiast

Table Of Contents

    What is SerrapeptasePIN

    What is Serrapeptase? Benefits, Side Effects and FAQ

    Pain and inflammation aren’t pleasant. It can make us go from party starter to party pooper the moment we notice an onset of discomfort in our muscles, joints, or spine.

    After weight-crushing workouts, juggling kids and heavy bags of groceries, or even just sitting at our desk for ours, it’s easy to grab the bottle of aspirin to get us through the day.

    You know, our ancestors didn’t pop out to the local pharmacy after a day of hunting or heavy labor. They found natural remedies in plants, herbs, and organisms to treat their illnesses and pain.

    In modern times, we find many of these natural remedies in the form of supplements. If you’re looking for one of the strongest natural painkillers, serrapeptase may be the supplement for you!

    What is Serrapeptase?

    Serrapeptase is available as a dietary supplement. We can find it along with other supplements like zinc, calcium, and vitamin D when we shop for natural health products.

    Also known as serratiopeptidase, serrapeptase is widely used in Europe and Japan as a natural, multi-purpose anti-inflammatory aid. Inflammation is the body’s natural response to infection, injury, and autoimmune conditions. We use anti-inflammatory medications like ibuprofen, aspirin, and naproxen when we have pain and swelling.

    Serrapeptase is an enzyme which helps to break down proteins, leading to less inflammation in the body. Along with its anti-inflammatory properties, the supplement has been found to have many potential uses and promising health benefits.

    Serrapeptase health benefits include:

    • Reduces inflammation
    • Reduces swelling
    • Enhances wound healing
    • Decreases pain
    • Helps break blood clots
    • Reduces cholesterol
    • Increases the effectiveness of antibiotics
    • Helps with respiratory issues

    Serrapeptase Enzyme

    Serrapeptase is a proteolytic enzyme. Also known as proteases, these enzymes break down proteins into smaller polypeptides or single amino acids. In the human body, the pancreas uses proteases to break down protein from food into amino acids, which are used for growth and tissue repairs.

    Researchers in Japan first discovered the serratiopeptidase enzyme in the 1960s. The microorganism was derived from the intestine of the silkworm Bombyx mori L. Silkworms use the enzyme to break down and digest their cocoons at birth, allowing them to emerge into lovely moths. Over the 1980s and 1990s, research institutions in Japan and Europe proposed that serrapeptase is one of the most effective agents in reducing inflammation among all enzyme preparations.

    How does Serrapetase work for Inflamation?

    Proteolytic enzymes like serrapeptase are thought to be a natural alternative to non-steroidal anti-inflammatory drugs (NSAIDs) and other anti-inflammatory drugs.

    Inflammation is the body’s natural response to injury, infection, and fluid retention. It is the key signal that tells us our vital functions are out of whack.

    Some of the main causes of inflammation include:

    • Elevated blood sugar
    • Injury
    • Infections
    • Food allergies
    • Stress
    • Lack of antioxidants

    Researchers believe that proteolytic enzymes work by facilitating immune cell migration from lymph nodes to inflamed and injured tissues.

    Serrapeptase Dosage

    Condition Daily Recommended

    Serrapeptase Dosage in MG

    Daily Recommended Serrapeptase Dosage in Serrapeptase Units (SPU)
    Inflammation and Pain Prevention 10 mg 20, 000 SPU
    Arthritis 20 mg 40,000 SPU
    Bronchitis 20 mg 40,000 SPU
    Cardiovascular 20 mg 40,000 SPU
    Injury 30 mg 60,000 SPU
    Post Surgery Recovery 30 mg 60,000 SPU
    Fertility Blocked Fallopian Tubes 40 mg 80,000 SPU
    Fibroids and Cysts 40 mg 80,000 SPU
    Anti-Viral 20mg 40,000 SPU
    Scar Tissue 60 mg 120,000 SPU

    Are you wondering, “How Much Serrapeptase Should I Take?”

    The recommended daily serrapeptase dosage is 10 mg to 30 mg for long-term use and up to 60 mg for short-term use. It is important to consult a healthcare practitioner before introducing serrapeptase as a dietary supplement. Serrapeptase dosage recommendations may differ for patients, depending on what medications and supplements they are already taking.

    When to Take Serrapeptase

    Serrapeptase must be taken on an empty stomach to obtain its anti-inflammatory benefits. An empty stomach is considered to be at least 45 minutes before or two hours after eating. If you take serrapeptase with a meal, your body will use the enzyme to digest the food in your intestines.

    That being said, serrapeptase will not eat up all your calories or digest your food for you! Taking serrapeptase with food will simply be a waste of your paycheck.

    Zohna Tip

    If you split up your serrapeptase dosage, keep the bottle in your bathroom and take one dose during the night when your stomach is empty.

    Serrapeptase Enteric Coated

    When choosing a serrapeptase supplement brand, it’s important to pick one which is labeled enteric-coated. Enteric-coating is a polymer applied to oral medications that need active ingredients to be delivered at the appropriate time of digestion. The coating permits the medication to pass through the acidic environment of the stomach before it is dissolved in the small intestines. For serrapeptase, enteric coating is necessary because the enzyme is absorbed in the digestive tract and transported to the bloodstream.

    Nattokinase vs Serrapeptase

    Serrapeptase and nattokinase are both proteolytic enzymes with anti-inflammatory benefits. While research shows that both enzymes share similar benefits, nattokinase is particularly effective for cardiovascular disorders due to its superior ability to dissolve blood clots.

    Nattokinase Serrapeptase
    Discovered in the 1980s as a way to treat cardiovascular disorders Discovered in the 1960s as a natural anti-inflammatory supplement
    Derived from fermented soybeans called ‘natto’ Derived from the intestines of silkworms.
    Anti-inflammatory & fibrin-degrading Anti-inflammatory & fibrin-dissolving
    Targets blood clots in the cardiovascular system Targets excess tissue in fibroids and scar tissue

    High Potency Serrapeptase

    High potency serrapeptase capsules contain the maximum recommended daily dose of serrapeptase, delivered in a single capsule.

    High potency serrapeptase

    • Contains 120,000 serrapeptase units (SPUs)
    • Equivalent to 60 mg
    • Take one capsule daily
    • Promotes and maintains healthy sinuses
    • Helps to break down unwanted proteins

    Regular serrapeptase capsules contain between 40,000 and 60,000 serrapeptase units (SPUS) or 20 to 30 mg. High potency serrapeptase should only be taken daily for a maximum of four weeks. For use beyond four weeks, we advise you to consult your doctor!

    Try Doctor’s Best High Potency Serrapeptase Enzyme for a vegan-friendly option!

    What is a Serrapeptase Biofilm?

    Serrapeptase is not a biofilm. A biofilm is a film that is formed by the growth of microorganisms, such as bacteria, yeast, or mold. The microorganisms form a proteinaceous matrix- a structure that holds the pathogenic bacteria in place.

    Certain yeast and bacterial infections can be particularly difficult to treat because of the stubborn biofilms which keep them in place. Serrapeptase breaks down and dissolves the biofilm, allowing the body to flush out the bacteria and speed up recovery.

    Think about a jello salad where the gelatin holds pieces of fruit together. Bacteria would be the pieces of fruit, and the biofilm is the jello which acts as the proteinaceous matrix!

    Serrapeptase Benefits

    Google, Google… Paging Doctor Google. You’ve probably seen many threads and discussion pages raving about all the serrapeptase benefits. In theory, the serrapeptase enzyme can aid with a variety of pain issues and chronic illnesses due to its three key properties:

    1. Anti-inflammatory: Reduces inflammation
    2. Proteolytic: Dissolves proteins
    3. Fibrinolytic: Dissolves Fibrins

    It’s important to keep note when consulting Doctor Google, videos on YouTube, and certainly the experts of Tik Tok that a lot of the advice is theoretical and lacks scientific evidence from clinical trials. Keeping that in mind, there are many ways where serrapeptase may benefit your pain and conditions.

    Serrapeptase for Scar Tissue

    • Dissolves fibrin proteins
    • Digests non-living tissues
    • Reduces inflammation to allow healing

    As a proteolytic enzyme, serrapeptase works to dissolve the fibrin proteins which make up scar tissue. Serrapeptase can digest non-living tissue by breaking down the proteins in dead cells and excess fibrin. By reducing inflammation, the body can clear out dead tissue and fibrin growths to promote a healthy healing process.

    Serrapeptase for Cancer

    • Boosts immune system
    • Reduces pain and inflammation
    • Supports digestion
    • Boost effectiveness of chemotherapy
    • Break down tumors

    While there is little evidence to suggest that serrapeptase directly benefits cancer, it is often used in enzyme therapy as a natural therapy for chronic illness, including cancer. The benefits of serrapeptase to break down proteins and dead tissue is thought to benefit symptoms associated with different types of cancer.

    Serrapeptase for Fertility

    • Dissolves ovarian cysts
    • Reduces inflammation from Polycystic Ovarian Syndrome (PCOS)
    • Unblocks fallopian tubes

    Natural fertility health practitioners swear by serrapeptase for fertility. Serrapeptase can help manage symptoms of some of the most common issues causing fertility. It is proposed that serrapeptase works by breaking down unnecessary proteins and tissues in the reproductive system, such as cysts and blockages in the fallopian tubes.

    Serrapeptase for Weight Loss

    • Reduces inflammation affecting insulin function
    • May assist overweight individuals

    If you’re thinking of using serrapeptase for weight loss, you may be disappointed. Contrary to what the experts on Reddit may have you believe, there is no direct benefit of taking serrapeptase to shed those extra pounds. Those who claim there is a correlation between serrapeptase and weight loss often experience it as a side effect of reduced inflammation; overweight individuals have higher levels of inflammation by default, which impairs the ability of insulin to function properly and store more fat cells.

    Serrapeptase for Endometriosis

    • Breaks down excess scar tissue caused by endometriosis
    • Reduces inflammation caused by excess scar tissue
    • Helps restore blood circulation to the reproductive system

    Endometriosis is a women’s reproductive health disorder, where tissue similar to the lining of the uterus grows outside the uterus, or endometrium, in places like the ovaries or fallopian tubes. The condition causes pelvic pain during menstruation and challenges with fertility. Evidence shows serrapeptase to be effective at reducing scar tissue, and can therefore aid in breaking down the excess tissue caused by endometriosis.

    Serrapeptase for Cysts

    • Digests non-living tissue
    • Reduces inflammation which can cause cysts
    • Decreases infection

    Cysts are pockets of membranous tissue filled with air, fluid, or sometimes bacteria resulting in infection. Taking serrapeptase for cysts is believed to work by digesting the non-living tissue and reducing the inflammation which causes cysts.

    Serrapeptase for Arthritis

    • Reduces inflammation
    • Decreases pain

    As we get older, arthritis, to some degree, is inevitable, as it is the degeneration of the tissue surrounding joints, leading to pain and, you guessed it, inflammation. While serrapeptase cannot magically restore the natural wear and tear of joint tissue, it can reduce inflammation.

    Serrapeptase for Sinus

    • Thins out and mobilizes excess mucus
    • Reduces neutrophils caused by infection
    • Decreases inflammation in the lungs

    Studies have shown the use of serrapeptase for sinus infections like bronchitis to be highly effective. Serrapeptase aids in clearing out excess mucus and the neutrophils caused by a response to respiratory infection. Additionally, its anti-inflammatory properties help decrease inflammation in the lungs.

    Serrapeptase for Fibroids

    • Dissolves non-living tissue
    • Reduces inflammation
    • Reduces swelling and fluid retention

    Fibroids are growths of muscle and connective tissue which grow in the female reproductive organs. They are quite common, and about 70-80% of women will develop them at some point in their life. For problematic fibroids causing pain or infertility, serrapeptase can help by dissolving the fibrous tissue and reducing inflammation and swelling in the uterus.

    Serrapeptase Dangers

    Overall, serrapeptase is considered a safe and effective natural anti-inflammatory agent with no significant side effects. However, it can have adverse effects on people taking certain medications or with certain illnesses.

    Some reported side effects of serrapeptase include:

    • Digestive upset
    • Skin irritation
    • Increased risk for bladder infections
    • Increased risk of bleeding and bruising
    • Muscle and joint pain

    Serrapeptase Side Effects Liver

    Evidence suggests serrapeptase improves cirrhosis of the liver by removing scar tissue caused by inflammation, allowing new cells to form. There is little evidence to suggest that serrapeptase causes side effects on the liver. However, you may need to cut back the dosage of serrapeptase if you have the following symptoms:

    • Skin rash
    • Yellow skin
    • Stomach pain
    • Frequent urination

    Serrapeptase Blood Clots

    One of the key benefits of serrapeptase for cardiovascular disorders is dissolving blots clots and lowering cholesterol levels. Serrapeptase should not be taken in addition to blood-thinning medications or other medications that thin the blood, including aspirin and ibuprofen, as it can cause internal bleeding.

    Serrapeptase Pneumonia

    In people with existing lung disease, serrapeptase may contribute to pneumonia by removing too much scar tissue and increasing the risk of respiratory infection. Doctors do not advise taking serrapeptase if you have lung cancer or are a heavy smoker.

    Serrapeptase Supplement

    Serrapeptase is most widely available in capsule form. You can also find serrapeptase liquid extract.

    Best Serrapeptase Brand

    Want to know the best serrapeptase brands? We've narrowed it down to three of the highest-rated products of serrapeptase.

    Doctor’s Best Serrapeptase

    Doctor's Best Serrapeptase
    $14.28 ($0.16 / Count)
    10/31/2023 02:11 am GMT

    Doctor’s Best Serrapeptase is a vegan-friendly supplement available in regular and high-potency serrapeptase. It features its own unique Serrateric coating, an alternative to enteric coating, designed to protect the enzyme until it reaches the digestive tract. The product helps promote healthy sinuses amongst other serrapeptase benefits.

    • 40, 000 & 120,000 SPU
    • Vegan
    • Gluten-Free
    • Non-GMO

    Serra-RX Ultra Pure Serrapeptase

    10/31/2023 02:35 am GMT

    Serra-RX Ultra Pure Serrapeptase is a gluten-free supplement available in 40,000 SPU and 80,000 SPU capsules. The product promotes its ultra-pure and concentrated formula of serrapeptase. It helps to promote sinuses and alleviate joint pain in addition to other serrapeptase benefits.

    • 40,000 & 80,000 SPU
    • Highly Concentrated
    • Enteric-Coated
    • Gluten-Free

    Absonutrix Serrapeptase Enzyme

    10/31/2023 02:41 am GMT

    Absonutrix Serrapeptase Enzyme is a unique liquid extract alternative to serrapeptase in capsules. It contains 250,000 SPU per dose making it the highest available high-potency serrapeptase formula. The product has a profound effect on inflammation management and immune system support.

    • 250,000 SPU
    • Liquid Extract
    • Potent Delivery
    • Manufactured in the USA


    • How Do You Know Serrapeptase Is Working?

      Improvement by serrapeptase as a painkiller or for respiratory illness can be felt within a few days to a week when taken daily. The effects of serrapeptase on ovarian cysts, fibroids, and internal scar tissue might only be determined by an ultrasound.

    • Can I Take Serrapeptase With Coffee?

      There is little evidence to suggest that serrapeptase and coffee cannot be taken at the same time. Some people report that the combination of coffee and serrapeptase on an empty stomach can cause nausea.

    • How Long Does It Take for Serrapeptase to Work?
      Approximate Time Serrapeptase Takes to Work
      Pain Relief 3 to 7 Days
      Reduced Inflammation 3 to 7 Days
      Bronchitis and Mucus Relief 3 Days
      Cysts 2 Weeks
      Fibroids 2 Weeks
      Scar Tissue 2 Weeks
    • Can I Take Serrapeptase and Drink Alcohol?

      Alcohol has blood-thinning effects for up to 24 hours after consumption. Consuming more than one or two alcoholic drinks while taking serrapeptase is not advised.

    • Signs Serrapeptase Is Working
      • Pain relief
      • Reduction in external inflammation
      • Less headaches
      • Clear sinuses
      • Less joint pain
      • Overall increase in wellness
    • Can You Take Serrapeptase During Period?

      There is no evidence to suggest that you should not take serrapeptase during your period. Some women find serrapeptase alleviates pain from menstrual cramps. If you take serrapeptase and experience more bleeding than normal, it is best to stop taking the supplement and consult your doctor.

    • Is Serrapeptase Safe?

      Serrapeptase is a safe, natural pain killer. Serrapeptase may not be safe if you are on blood-thinning medications or have certain types of chronic illness.

    • Does Serrapeptase Thin the Blood?

      Yes. Serrapeptase is a natural blood thinner.

    Serrapeptase: Nature’s Secret Painkiller

    Serrapeptase is nature’s secret painkiller. What was once hidden within the digestive system of silkworms is now an enzyme in the form of a dietary supplement, readily available at your local natural health store or a click away online! Love our nutrition-related content? Head over to this article and discover the benefits of star anise!